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. 2015 Jun 23;20(6):11569–11603. doi: 10.3390/molecules200611569

Figure 2.

Figure 2

Crystal structure of complex of AMA1-RON2 peptide (PDB ID:3ZWZ). AMA1 is shown as the surface and RON2 is shown in magenta. Amino acids from AMA1 that are critical for binding are labeled with three-letter codes. Amino acids from RON2 that are critical for binding and used in the design of the pharmacophore model are shown as sticks (magenta) and labeled with single letter codes for amino acids. Four point pharmacophore (shown with circles) was generated based on the PPI interaction. However, Tyr251 was in the exclusion sphere in the pharmacophore generated [204]. PyMol (Schrodinger LLC, Portland, OR, USA) was used to generate the figure based on the information from Pihan et al. [204].