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(A) Linkage region of GAGs illustrating the amino acid sequence within the PG protein core (serine (Ser), glycine (Gly) and aspartic acid (Asp)) required for covalent attachment of initial saccharide of the linkage region, xylose, where addition of GlcNAc via EXT is where GAG becomes a HS/heparin and diverges from CS synthesis route. (B) Comparison of disaccharide unit structures of HS and heparin and the functional groups present within tissues.
