Table 7.
Overview of decreased biomarker candidates and correlation to previously published proteomic studies of secondary changes in animal models of dystrophinopathy.
| Protein Name | Tissue Localization | Animal Models | Skeletal Muscles | References |
|---|---|---|---|---|
| Parvalbumin | Cytoplasm | mdx, mdx-4cv | DIA, FDB, GAS, INT, SOL | [24,33,35,37] |
| Myoglobin | Cytoplasm | mdx | DIA, EDL, FDB, SOL | [24,37] |
| Fatty acid-binding protein FABP3 | Cytoplasm | mdx | DIA, SOL, GAS | [33,37] |
| Carbonic anhydrase CA3 | Cytoplasm | mdx | DIA | [21] |
| Perilipin | Cytoplasm | mdx, mdx-4cv | DIA, FDB | [35] |
| Myozenin | Actin cytoskeleton | mdx, mdx-4cv | DIA, EDL, FDB, GAS | [34,35] |
| Glycogen phosphorylase, muscle | Cytoplasm | mdx, mdx-4cv | DIA, EDL, GAS | [23,24,35] |
Abbreviations used: DIA, diaphragm; EDL, extensor digitorum longus; FDB, flexor digitorum brevis; GAS, gastrocnemius; INT, interosseus; SOL, soleus.