Table 1.

Results of the screening of compounds 1–10 on schistosomula (Phenotypes: D = dead, Deg = degenerate, O = overactive, R = round; severe phenotypes are in bold). PZQ = Praziquantel.

					Observed Phenotype After (c = 5 μM)
Compound	R1	R2	R3	R4	24 h	48 h	72 h	J774.1 [μM] [15]
1	-OH	-OH	-H	-H	-	-	-	8.3
2	-OH	-OCH3	-H	-H	R	R, Dark	R, Dark	48.7
3	-H	-H	-H	-H	-	R, Dark	R, Deg	45.2
4	-H	-H	-Cl	-Cl	R	-	-	58.9
5	-H	-Cl	-H	-Cl	R	-	-	60.6
6	-H	-OCH3	-H	-H	R	-	-	42.6
7	-H	-Br	-H	-H	R	-	Dark	54.6
8	-H	-N(CH3)2	-H	-H	R	-	-	>100
9	-H	-OBn	-H	-H	R	-	-	>100
10	-H	-Cl	-H	-H	-	Dark	-	49.5
PZQ	-	-	-	-	O, Dark	O, Deg	Deg	-