Table 2.

Results of the screening of compounds 11–30 on schistosomula (Phenotypes: D = dead, Deg = degenerate, O = overactive, R = round, V = vacuoles; severe phenotypes are in bold). PZQ = Praziquantel.

				Observed Phenotype After (c = 5 μM)
Compound	R1	R2	R3	24 h	48 h	72 h	J774.1 [μM] [15]
11	isoborneol	-OH	-OH	-	-	-	8.8
12	isoborneol	-OH	-OCH3	-	R	-	44.3
13	isoborneol	-H	-H	-	-	-	46.0
14	isoborneol	-H	-NO2	-	-	-	>100
15	cyclohexanol	-H	-H	-	-	-	>100
16	geraniol	-H	-H	-	-	-	>100
17	adamantol	-H	-H	-	-	-	46.7
18	4-thujanol	-H	-H	-	-	-	>100
19	naphthol	-H	-H	-	-	-	44.5
20	α-bisabolol	-H	-H	R	R	-	>100
21	thymol	-OH	-OH	O	-	-	8.8
22	thymol	-OH	-OCH3	-	R, Dark	Dark, R	45.6
23	thymol	-H	-H	Deg, V	Deg, V	Deg	44.8
24	menthol	-OH	-OH	-	R, Dark	Dark, R	2.0
25	menthol	-OH	-OCH3	R	R, Dark	R, Deg	45.6
26	menthol	-H	-H	R	R, Dark	R, Deg	44.8
27	eugenol	-H	-H	Deg, V	Deg	D	32.2
28	thymol	-	-	-	-	-	>100
29	eugenol	-	-	-	-	-	>100
30	borneol	-	-	-	-	-	>100
PZQ	-	-	-	O, R	O, Deg	Deg	-