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Synthesis route to NAH compounds.
Reagents and conditions: (a) NH2NH2·H2O 64%, EtOH, reflux, 48 h, 79%; (b) aromatic aldehyde, EtOH, room temperature, 30–90 min, 46%–99%; (c) (1) SOCl2, DMF (cat.), room temperature, 4 h; (2) NH2NH2·H2O 64%, CH2Cl2, 0 °C, 2 h; (d) 2-thiophenecarboxaldehyde, EtOH, room temperature, 30 min, 51%; (e) as previously described [19,20].
