Scheme 15.
Synthesis of 3'-C-phenyl d4T 126.
Reagents and Conditions: (i) Bu3SnOMe, 90 °C, 1.5 h; (ii) LTMP, TMEDA, THF, −70 °C, 15 min, 124: 60%, 125: 9% for the two steps; (iii) PhI, Pd(PPh3)4, CuI, DMF, rt, 12 h, 97%.
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