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CAIs designed to target the extracellular CA domain of CA IX as compared to classic inhibitors. (A) Classic (B) Bulky (C) Fluorescent (D) Cationic sulfonamides (E) Glycoconjugates all show extensive differences in terms of CA IX specific targeting potential.(Figure was adapted from [67] and made using PyMol [28] and ChemDraw [68] software packages).
