Table 2.

Bioactivities of compounds 5h–v.

Compound	IC50 a (μM)
	EZH2(AlphaLISA)	HCT15	MDA-MB-231
5h	11.5 ± 1.21	5.46 ± 0.85	4.31 ± 0.57
5i	17.4 ± 1.07	>20	15.7 ± 1.27
5j	4.20 ± 0.20	18.6 ± 2.20	12.4 ± 0.95
5k	1.20 ± 0.11	7.60 ± 0.46	2.45 ± 0.24
5l	2.80 ± 0.21	15.5 ± 0.20	2.40 ± 0.49
5m	19.7 ± 2.56	18.9 ± 1.97	>20
5n	26.4 ± 2.04	14.6 ± 1.27	13.2 ± 2.53
5o	17.5 ± 1.13	>20	>20
5p	27.6 ± 0.97	17.4 ± 1.54	16.2 ± 1.67
5q	34.8 ± 1.54	16.9 ± 0.36	14.5 ± 1.23
5r	39.7 ± 1.26	12.9 ± 0.89	>20
5s	16.8 ± 0.94	19.6 ± 0.56	16.9 ± 1.06
5t	35.3 ± 1.61	>20	>20
5u	26.2 ± 2.54	17.8 ± 1.27	14.9 ± 2.20
5v	34.1 ± 2.22	10.2 ± 1.24	>20

^a Values are means of at least three measurements.