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. 2015 Jun 4;20(6):10342–10359. doi: 10.3390/molecules200610342

Table 1.

Chemical structures and replicon assay results of compounds 1–17 a.

graphic file with name molecules-20-10342-i001.jpg

Compound R1 R2 R3 Anti-HCV JFH1-2a Replicon Assay EC50 (μM) ± SD b
1 graphic file with name molecules-20-10342-i002.jpg OH OH 0.92 ± 0.12
2 graphic file with name molecules-20-10342-i003.jpg OH OH >10
3 graphic file with name molecules-20-10342-i004.jpg OH OH >50
4 graphic file with name molecules-20-10342-i005.jpg OH OH >50
5 graphic file with name molecules-20-10342-i006.jpg Cl H >50
6 graphic file with name molecules-20-10342-i007.jpg NO2 H >50
7 graphic file with name molecules-20-10342-i008.jpg CN H >50
8 graphic file with name molecules-20-10342-i009.jpg F H 1.65 ± 0.32
9 graphic file with name molecules-20-10342-i010.jpg CF3 H >10
10 graphic file with name molecules-20-10342-i011.jpg MeS H >50
11 graphic file with name molecules-20-10342-i012.jpg F F >50
12 graphic file with name molecules-20-10342-i013.jpg F MeS >50
13 graphic file with name molecules-20-10342-i014.jpg Cl MeO >50
14 graphic file with name molecules-20-10342-i015.jpg graphic file with name molecules-20-10342-i022.jpg OH 0.55 ± 0.03
15 graphic file with name molecules-20-10342-i016.jpg graphic file with name molecules-20-10342-i021.jpg graphic file with name molecules-20-10342-i024.jpg 0.46 ± 0.05
16 graphic file with name molecules-20-10342-i017.jpg graphic file with name molecules-20-10342-i020.jpg OH >20
17 graphic file with name molecules-20-10342-i018.jpg graphic file with name molecules-20-10342-i019.jpg graphic file with name molecules-20-10342-i023.jpg >20
CsA 1.16 ± 0.14

a The synthesis and HPLC analysis data of 1–13 was according to reference [29]; the synthesis of 16–17 was described in the Supporting Information; The experimental method was described in the “Virus Assay” of the “Method”; b Each value indicates the mean ± SD of three independent experiments.