Table 12.

Pharmacokinetic parameters of SSa and SSd in rats with intravenous administration of SSa-SSd-Lip and SSa-SSd-Sol (mean ± SD, n = 6).

Parameter	SSa-SSd-Liposome		SSa-SSd-Solution
	SSa	SSd	SSa	SSd
T1/2β (min)	399.8 ± 23.7	346.8 ± 34.1	127.9 ± 22.4	140.3 ± 19.8
MRT (min)	233.9 ± 53.2	228.2 ± 35.9	126.1 ± 17.9	141.5 ± 11.5
Vc (mL/kg)	1404.7 ± 87.2	1301.3 ± 74.8	2050.9 ± 328.2	2015.2 ± 268.0
CL (mL·mg/min)	2.4 ± 0.37	2.6 ± 0.33	11.3 ± 2.58	10.0 ± 3.76
AUC0–t (μg·min/mL)	291.0 ± 67.5	290.8 ± 86.9	87.3 ± 20.1	96.7 ± 15.4
AUC0–∞ (μg·min/mL)	410.6 ± 79.3	384.5 ± 103.4	90.0 ± 18.3	100.4 ± 37.4