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Time dependence of the reductive amination of the indole-2-carbaldehydes 7 and 8 with 1-(4-fluorophenyl)piperazine yielding [18F]FAUC 316 ([18F]1) and the corresponding ligand [18F]9 without a nitrile substituent for comparison. Reaction conditions: NaBH3CN, AcOH, DMSO, 110 °C.
