Table 2.

Sequence of the two-step radiosynthesis of n.c.a. 2-((4-(4-[¹⁸F]fluorophenyl)-piperazin-1-yl)methyl)-1H-indole-5-carbonitrile ([¹⁸F]FAUC 316).

Structures	Time (min)	RCY (%)	Compounds and Conditions
	0		Drying process
	5	100
			Addition of iodonium ylide 3c
	15	70	Heating at 110 °C
		60	Purification step
			Addition of piperazine and HBC reagents
	30	47	Heating at 100 °C
		37	Purification step
			Addition of 2-formyl-1 H-indole-5-carbonitrile and NaBH3CN
			Stirring
	45	28
			Pre-purification
			HPLC-separation
	80	10	Formulation