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Affinity of the selected triazole-CPX hybrids towards bacterial type II topoisomerases obtained from Escherichia coli and Staphylococcus aureus.
| IC50 [μM] | ||||
|---|---|---|---|---|
| Escherichia coli | Staphylococcus aureus | |||
| gyrDNA | topoIV | gyrDNA | topoIV | |
| 24 | 3.5 | 80.0 | 55.0 | 15.5 |
| 25 | 1.2 | 56.0 | 164.0 | 19.0 |
| 39 | 3.2 | 66.0 | 68.0 | 22.0 |
| Ciprofloxacin | 0.15 | 80.0 | >100.0 | 4.0 |
