Table 1.

MicroRNAs implicated in inflammatory response whose expression was modified by different phenolic natural products, and their main target transcripts and pathways.

Molecules	Effects on microRNAs	Cells/Animals	Main Target Transcripts or Pathways	References
Resveratrol	miR-663 up	THP-1 cells	JunD and JunD; Impairs miR-155 up-regulation	[60]
Resveratrol	miR-663 up	SW480 cells	TGF-β1 transcripts and SMAD2/SMAD3/SMAD4 pathway	[19]
Resveratrol	miR-Let7A up	THP-1 cells	TNF, IL-6, IL-10, BDNF and ASK1 pathways	[64]
Resveratrol	miR-21 down	U251 brain tumor cells	NF-κB pathway	[88]
Pomegranate polyphenols	miR-155 down	MCF-10F and MCF-12F cells	PI3K/AKT and NF-κB pathways	[68]
Chilean propolis polyphenols	miR-20b, miR-106a, and miR-181a up	Atherosclerotic plaques of LDL receptor knockout mice	HIF-1α, ERK1/2 and VEGF pathways	[35]
Mango extracts	miR-126 up	CCD-18Co cells	PI3K(p85β) transcripts and PI3K/AKP/mTOR pathway	[72]
Cowpea (Vigna unguiculata) polyphenols	miR-126 up	CCD-18Co cells	VCAM-1 transcripts; TNF, IL8 and NF-κB pathways	[74]
Pomegranate juice polyphenols	miR-126 up	Colon mucosa of rats injected with azoxymethane (AOM) subcutaneously	PI3K(p85β) and VCAM-1 transcripts; iNOS, COX-2 and NF-κB pathways	[75]
Honokiol	miR-34a up	Human breast cancer cell lines	Wnt1 transcripts; Wnt1-MTA1-β-catenin pathway	[79]
Pomegranate rind polyphenols	miR-34a up	EJ bladder cancer cells	c-Myc and CD44 transcripts	[80]
Curcumin	miR-181b up	MDA-MB-231 human breast cancer cells	CXCL1 and CXCL2 transcripts	[82]
Curcumin	miR-205-5p and other microRNAs up	Murine melanoma	Proliferation and metastatic pathways; O-glycan biosynthesis; Endoplasmic reticulum protein maturation and/or processing	[83]
Apigenin	miR-122 down	Human Huh7 cells	miR-122 positively regulates hepatitis C replication in enhancing viral translation	[15]
Apigenin	miR-103 down	(miR103)-overexpressing transgenic mic presenting with glucose intolerance	TRBP phosphorylation; Improvement of pathogenic status	[84]
EGCG	miR-210 up	Mouse lung adenocarcinoma cell line CL13	Pathways implicated in cell-proliferation and anchorage-independent growth	[86]
EGCG or EGC	miR-7-1 up, and miR-92, miR-93, and miR-106b down	SH-SY5Y and SK-N-DZ neuroblastoma cell lines	Apoptosis pathway	[90]
EGCG	12 microRNAs up, and 9 microRNAs down	A/J mice lung adenoma	AKT, MAP kinases and NF-κB and cell cycle regulation pathways	[92]