Table 1.

Proteins differentially expressed in response to iron overload in HH4 cells.

Ratio 1	Protein IDs	Protein Description	Gene Name	MW [kDa] 2
−1.781	Q92896	Golgi apparatus protein 1	GLG1	135
−1.602	Q9NZN4	EH domain-containing protein 2	EHD2	61
−1.437	P09972	Fructose-bisphosphate aldolase C	ALDOC	39
−1.091	P42126	Isoform 2 of Enoyl-CoA delta isomerase 1, mitochondrial	ECI1	31
−1.09	P07996	Thrombospondin-1	THBS1	129
−0.983	P09603	Macrophage colony-stimulating factor 1	CSF1	60
−0.977	Q92522	Histone H1x	H1FX	22
−0.956	O95197	Isoform 3 of Reticulon-3	RTN3	26
−0.927	P21399	Cytoplasmic aconitate hydratase	ACO1	98
−0.895	Q15418	Isoform 3 of Ribosomal protein S6 kinase α-1	RPS6KA1	73
−0.845	P07203	Glutathione peroxidase 1	GPX1	22
−0.814	Q8TED1	Probable glutathione peroxidase 8	GPX8	24
−0.793	Q16678	Cytochrome P450 1B1	CYP1B1	61
−0.768	Q6EMK4	Vasorin	VASN	72
−0.749	P51580	Thiopurine S-methyltransferase	TPMT	28
−0.745	Q969V3	Isoform 2 of Nicalin	NCLN	63
−0.733	O00622	Protein CYR61	CYR61	42
−0.729	P06865	β-Hexosaminidase	HEXA	58
−0.7	P04179	Superoxide dismutase [Mn], mitochondrial	SOD2	25
−0.693	P17342	Isoform 2 of atrial natriuretic peptide receptor 3	NPR3	60
−0.685	P07602	Proactivator polypeptide	PSAP	58
−0.661	O43865	Putative adenosylhomocysteinase 2	AHCYL1	59
−0.657	P52630	Signal transducer and activator of transcription 2	STAT2	97
−0.657	P51553	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	43
−0.648	P61970	Nuclear transport factor 2	NUTF2	14
−0.647	Q9ULZ3	Apoptosis-associated speck-like protein containing a CARD (PYD and CARD domain containing)	PYCARD	22
−0.639	P30626	Sorcin	SRI	18
−0.637	P0DMM9	Sulfotransferase 1A3	SULT1A3	34
−0.617	Q9H845	Acyl-CoA dehydrogenase family member 9, mitochondrial	ACAD9	69
−0.615	P53634	Dipeptidyl peptidase 1	CTSC	52
−0.613	Q6P587	Acylpyruvase FAHD1, mitochondrial	FAHD1	25
−0.609	P16403	Histone H1.2	HIST1H1C	21
−0.602	P62805	Histone H4	HIST1H4A	11
−0.59	P04844	Isoform 2 of Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 2	RPN2	68
−0.588	Q13228	Selenium-binding protein 1	SELENBP1	52
0.586	P05362	Intercellular adhesion molecule 1	ICAM1	58
0.597	Q9Y6H1	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial	CHCHD2	16
0.601	Q9Y371	Endophilin-B1	SH3GLB1	41
0.61	P05161	Ubiquitin-like protein ISG15	ISG15	18
0.614	P31689	DnaJ homolog subfamily A member 1	DNAJA1	45
0.614	P11387	DNA topoisomerase 1	TOP1	91
0.621	P31153	S-adenosylmethionine synthase isoform type-2	MAT2A	44
0.636	Q14498	Isoform 3 of RNA-binding protein 39	RBM39	57
0.636	O75534	Isoform Short of Cold shock domain-containing protein E1	CSDE1	86
0.643	P02786	Transferrin receptor protein 1	TfR1	85
0.653	O75976	Carboxypeptidase D	CPD	153
0.656	Q9BQ52	Zinc phosphodiesterase ELAC protein 2	ELAC2	92
0.67	Q9UI12	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, isoform CRA_c	ATP6V1H	52
0.678	P48729	Casein kinase 1, alpha 1, isoform CRA_g	CSNK1A1	38
0.681	P08473	Neprilysin	MME	86
0.685	Q9H2H9	Sodium-coupled neutral amino acid transporter 1	SLC38A1	54
0.692	P08195	Isoform 2 of 4F2 cell-surface antigen heavy chain	SLC3A2	58
0.702	Q9H5Q4	Dimethyladenosine transferase 2, mitochondrial	TFB2M	45
0.712	P29317	Ephrin type-A receptor 2	EPHA2	108
0.714	O14786	Neuropilin-1	NRP1	101
0.723	P11279	Lysosome-associated membrane glycoprotein 1	LAMP1	39
0.726	Q96PD2	Discoidin, CUB and LCCL domain-containing protein 2	DCBLD2	85
0.747	P16070	CD44 antigen (Fragment)	CD44	20
0.754	P46734	Dual specificity mitogen-activated protein kinase kinase 3	MAP2K3	39
0.765	P08754	Guanine nucleotide-binding protein G(k) subunit alpha	GNAI3	41
0.766	Q9H5V8	CUB domain-containing protein 1	CDCP1	93
0.777	Q13641	Trophoblast glycoprotein	TPBG	46
0.809	P02795	Metallothionein-2	MT2A	6
0.811	Q14978	Nucleolar and coiled-body phosphoprotein 1	NOLC1	74
0.825	P52926	High mobility group protein HMGI-C	HMGA2	11
0.833	P08962	CD63 antigen	CD63	16
0.837	P32455	Interferon-induced guanylate-binding protein 1	GBP1	68
0.837	P04183	Thymidine kinase, cytosolic	TK1	25
0.848	Q16831	Uridine phosphorylase 1	UPP1	34
0.858	P21980	Protein-glutamine gamma-glutamyltransferase 2	TGM2	69
0.875	P35080	Profilin-2	PFN2	10
0.882	P13726	Tissue factor	F3	33
0.885	P56945	Breast cancer anti-estrogen resistance protein 1	BCAR1	93
0.891	O15118	Niemann-Pick C1 protein	NPC1	142
0.892	Q14669	E3 ubiquitin-protein ligase TRIP12	TRIP12	220
0.92	Q12996	Cleavage stimulation factor subunit 3	CSTF3	83
0.935	Q9H4A6	Golgi phosphoprotein 3	GOLPH3	34
0.942	Q16850	Isoform 2 of lanosterol 14-α demethylase	CYP51A1	46
0.962	P11802	Cyclin-dependent kinase 4	CDK4	34
0.97	Q9Y3E0	Vesicle transport protein GOT1B	GOLT1B	14
0.975	Q9Y3D8	Transcription initiation factor TFIID subunit 9	AK6	17
0.983	Q9UBB6	Isoform 2 of neurochondrin	NCDN	77
1.003	P17844	Probable ATP-dependent RNA helicase DDX5	DDX5	107
1.028	P05120	Plasminogen activator inhibitor 2	SERPINB2	47
1.085	P11234	Ras-related protein Ral-B	RALB	23
1.127	Q96QD8	Sodium-coupled neutral amino acid transporter 2	SLC38A2	56
1.162	P52292	Importin subunit alpha-1	KPNA2	58
1.539	P40189	Interleukin-6 receptor subunit beta	IL6ST	104
1.54	Q06481	Amyloid-like protein 2	APLP2	76
1.742	P05067	Gamma-secretase C-terminal fragment 59	APP	81
2.309	P09914	Interferon-induced protein with tetratricopeptide repeats 1	IFIT1	55
2.408	P02787	Serotransferrin	TF	78
2.809	O60603	Toll-like receptor 2	TLR2	90

¹: LOG (FAC/Veh, 2); ²: MW: relative molecular mass (MW) generated by the MS system.