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. 2016 Sep 21;21(9):1258. doi: 10.3390/molecules21091258

Figure 4.

Figure 4

Effects of VH02 on VEGF-mediated signaling pathway through VEGFR2, Akt, FAK and P38 in EA.hy926 cells. The protein phosphorylation of VEGF receptor-2 (p-VEGFR2), Akt (p-Akt), FAK (p-FAK), and P38 (p-P38) was analyzed by western blot analysis as described in the Materials and Methods section. (A) Representative blots show protein phosphorylation signals relative to the non-phosphorylated proteins; (B) Changes in VEGFR2 phosphorylation; (C) Changes in Akt phosphorylation; (D) Changes in FAK phosphorylation; (E) Changes in P38 phosphorylation. Values were represented as mean ± SEM. * p < 0.05; ** p < 0.01 versus vehicle control; Δ p < 0.05; ΔΔ p < 0.01; n.s. non-significant versus VEGF alone.