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. 2016 Jun 18;21(6):794. doi: 10.3390/molecules21060794

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Sequential MCR procedure for convenient synthesis of 6-amino-3-cyclopropylquinazolin-4(3H)-one (3) from 1. Reagents and conditions: (a) Step 1: DMFDMA (2.5 equiv), DMF, 100 °C (µw), 15 min; Step 2: Cyclopropylamine (1.1 eq), AcOH, 100 °C (µw), 15 min; 85%; (b) HCO₂NH₄ (5.0 equiv), Pd/C (10%), EtOH, 85 °C (μw), 15 min; 85%.