Table 1.

Chemical structures and yields obtained for the synthesis of series 7a–l.

-R a	Compound	Method	Time (h)	Yield b (%)
Ph	7a	A/B	1/2	84/80
4-Cl-C6H4	7b	A	1	91
4-F-C6H4	7c	B	2	90
4-CF3-C6H4	7d	Bc	1	84
4-NO2-C6H4	7e	A	0.5	74
2,4-diCl-C6H3	7f	B	1	89
3-Py	7g	Bc	2	89
4-Me-C6H4	7h	A	2	89
4-OMe-C6H4	7i	A	2	87
4-NMe2-C6H4	7j	B	10 min	87
2,4-diOMe-C6H3	7k	B	5 min	97
3,4-diOMe-C6H3	7l	B	5 min	88

^a This list of anilines was established, based on the Topliss schemes [42], in order to get the most potent compounds as early as possible; ^b Isolated yield; ^c heated for 1 h at 40 °C under microwaves.