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. 2016 Jun 14;21(6):738. doi: 10.3390/molecules21060738

Table 4.

Effects of flavonoids on CYP3A4 isozyme activities (x ± s, n = 3).

Concentration (μM) Inhibition Rate (%)
Ketoconazole Quercetin Kaempferol Isoquercitrin Astragalin
5 87.28 ± 6.55 33.18 ± 1.96 26.20 ± 1.81 16.68 ± 1.00 6.65 ± 0.41
1 76.11 ± 5.25 24.97 ± 1.77 20.00 ± 1.28 13.31 ± 0.63 2.57 ± 0.19
0.2 47.33 ± 3.08 22.41 ± 1.46 17.70 ± 0.80 13.04 ± 1.11 2.22 ± 0.14
0.1 22.95 ± 1.08 15.79 ± 1.23 14.12 ± 0.55 10.62 ± 0.62 0.51 ± 0.04
0.02 14.72 ± 0.56 15.04 ± 0.83 10.98 ± 0.87 9.03 ± 0.35 0.42 ± 0.04