Table 1.
Main families of Pattern Recognition Receptors.
| Name | Localization | Ligands | Actions |
|---|---|---|---|
| TLR (1 to 13 1) | Trans membrane (cell, endosome) | Pathogen fragments | NF-κB activation Production of immunomodulatory cytokines and chemokines |
| CLRs | Trans membrane or soluble | Carbohydrates | |
| NLRs (NODs) | Intracytoplasmic | Peptidoglycans | Production of IL-1β IL-18 Pyroptosis |
| RLHs | Intracytoplasmic | Ribonucleic acids | |
| AIMs | Intracytoplasmic | Deoxyribonucleic acids |
TLRs: Toll-like Receptors, CLRs: C-type Lectin Receptors, NLRs: Nucleotide-binding domain and Leucin-rich repeat Receptors, RLH: Retinoic acid-inducible gene Like Helicase Receptors, AIMs: Absent in Melanoma receptors. 1: number vary according to animal species.