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Immunosuppressive effects of mesenchymal stem cells. MSCs excrete various cytokines that mediate immunosuppression of T-cells, B-cells, natural killer cells (NK) and dendritic cells (DC). Some mediators, like prostaglandin E2 (PGE2), exhibit an immunosuppressive effect on all immune cells, whereas others, like IL-15, are specific inhibitors of single cell types.
