. 2016 Sep 21;21(9):1261. doi: 10.3390/molecules21091261

Table 3.

ED₅₀ values (±95% confidence limits) of the OJe, HES and NRTN on audiogenic seizures in DBA/2 mice. All data are expressed in mg/kg and were calculated according to the method of Litchfield and Wilcoxon (1949). The significant changes were statistically evaluated according to Lichtfield and Wilcoxon. ** p < 0.01.

Treatment	Time (min)	ED₅₀ Values
Treatment	Time (min)	Clonus	Tonus
OJe	30	71.89 (56.75–91.08) **	36.34 (25.49–51.82) **
HES	30	112.05 (81.85–153.40)	57.54 (47.33–69.95)
NRTN	30	>120	66.65 (48.49–91.22)