Table 4.

ED₅₀ values (±95% confidence limits) of the OJe co-administrated with NMDA antagonists on audiogenic seizures in DBA/2 mice. All data are expressed in mg/kg and were calculated according to the method of Litchfield and Wilcoxon (1949). The significant changes were statistically evaluated according to Lichtfield and Wilcoxon. * p < 0.05; ** p < 0.01.

Treatment			ED50 Values
			Clonus	Tonus
CPPene	plus	Saline	1.76 (1.21–2.26)	0.79 (0.44–1.43)
	plus	OJe	2.69 (2.30–3.15) **	2.61 (2.04–3.33) **
d-cycloserine	plus	Saline	27.6 (17.7–43.2)	14.4 (7.8–26.5)
	plus	OJe	58.7 (37.4–92.3) **	28.3 (20.1–39.8) **
Felbamate	plus	Saline	48.8 (35.4–67.2)	23.1 (12.1–44.0)
	plus	OJe	105.6 (64.9–171.7) **	65.9 (38.5–112.8) **
NBQX	plus	Saline	4.9 (3.2–7.5)	2.2 (1.4–3.6)
	plus	OJe	4.1 (2.6–6.49)	2.8 (2.05–3.73)
CFM–2	plus	Saline	10.04 (11.3–13.1)	9.42 (7.34–12.09)
	plus	OJe	15.9 (11.3–22.46) *	10.78 (7.59–15.30)