Table 1.
Inhibition of LPS + IFN-γ induced nitric oxide and TNF-α (Tumor Necrosis Factor-alpha) production as well as cytotoxicity of compounds 1–6 in comparison to classical NSAIDs (statistical analysis is provided in Supplementary Materials Table S7).
| Compound | NO Inhibition (IC50 in μM) (n = 8) | TNF-α Inhibition (IC50 in µM) (n = 3) (in μM) (IC50 in μM) | Cytotoxicity (LC50 in μM) (n = 8) | Therapeutic Index (TI) (Compared to NO) |
|---|---|---|---|---|
| 1 | >36 | >36 | >36 | |
| 2 | 17.6 ± 0.7 | 22.7 ± 1.1 | 18.6 ± 0.8 | 1 |
| 3 | 1.7 ± 0.3 | 10.9 ± 2.3 | 4.8 ± 0.9 | 2.8 |
| 4 | 3.5 ± 0.5 | 5.6 ± 0.4 | 8.0 ± 0.3 | 2.3 |
| 5 | 8.3 ± 1.0 | 23.5 ± 3.7 | 29.1 ± 4.4 | 3.5 |
| 6 | 14.7 ± 0.6 | >36 | 13.1 ± 2.5 | 0.9 |
| NSAID | ||||
| Diclofenac | 217 ± 43 | >333 | >333 | |
| Ibuprofen | 1155 ± 133 | 723 ± 261 | >1500 |