Table 3.
Pharmacokinetic parameters of maleic acid after intravenous administration.
| Parameters | 10 mg/kg, i.v. | 30 mg/kg, i.v. |
|---|---|---|
| Blood | ||
| AIC of one-compartment | 18 ± 2 | 46 ± 2 |
| AIC of two-compartment | 25 ± 3 | 49 ± 2 |
| AUC (min∙µg/mL) | 376 ± 33.4 | 1236 ± 124 |
| Cmax (µg/mL) | 10.9 ± 1.08 | 32.1 ± 5.17 |
| T1/2 (min) | 24.1 ± 1.19 | 28.4 ± 3.20 |
| CL (mL/min/kg) | 27.4 ± 2.38 | 25.3 ± 2.54 |
| MRT (min) | 34.7 ± 1.72 | 40.9 ± 4.62 |
| Vd (mL/kg) | 975 ± 113 | 1050 ± 191 |
| AUC/Dose | 37.6 | 41.2 |
| Kidney | ||
| Non-compartment | ||
| AUC (min∙µg/mL) | 1997 ± 355 | 6784 ± 1538 |
| Cmax (µg/mL) | 41.4 ± 5.04 | 134 ± 35.6 |
| T1/2 (min) | 32.1 ± 5.69 | 22.3 ± 3.18 |
| CL (mL/min/kg) | 5.45 ± 1.06 | 5.34 ± 1.15 |
| MRT (min) | 31.8 ± 1.10 | 32.7 ± 2.16 |
| Vd (mL/kg) | 209 ± 36.5 | 182 ± 41.9 |
| AUC/Dose | 199.7 | 226.1 |
| AUC ratio of (AUCkidney/AUCblood) | 5.31 | 5.49 |
Data expressed as mean ± S.E.M. (n = 5). AUC, area under the concentration versus time curve; Cmax, the peak plasma concentration of a drug after administration; T1/2, elimination half-life; CL, total body clearance; MRT, mean residence time; Vd, volume of distribution; the AUC ratio (AUCkidney/AUCblood) in the kidneys and the blood was used to define the distribution of kidney-to-blood maleic acid.