Table 2.
Inhibitory effect of OA-n on HBsAg and HBeAg secretion in HepG2.2.15 cells. Data are expressed as inhibitory ratio ± SD based on three independent experiments.
| Compound | Concentration (μg/mL) | 3 Day | 6 Day | ||
|---|---|---|---|---|---|
| HBsAg (%) | HBeAg (%) | HBsAg (%) | HBeAg (%) | ||
| OA-1 | 6.25 | 5.03 ± 1.42 | 10.57 ± 3.72 | 0.42 ± 1.56 | −10.01 ± 4.37 |
| OA-2 | 6.25 | −11.96 ± 3.21 | −29.0 ± 0.46 | −6.67 ± 2.40 | −20.33 ± 7.53 |
| OA-3 | 6.25 | 17.53 ± 3.09 | 1.15 ± 1.31 | 17.33 ± 4.74 | 3.56 ± 2.12 |
| OA-4 | 1.56 | 36.48 ± 4.82 | 13.03 ± 3.17 | 20.21 ± 3.67 | 33.68 ± 4.03 |
| OA-5 | 6.25 | 16.68 ± 4.64 | 6.78 ± 3.24 | 13.22 ± 2.83 | 8.54 ± 3.95 |
| OA-6 | 1.56 | −15.50 ± 5.80 | −16.88 ± 5.96 | 3.76 ± 1.65 | −30.06 ± 7.32 |
| 3TC | 6.25 | 4.68 ± 2.73 | 6.31 ± 4.31 | 6.85 ± 2.58 | −16.12 ± 4.55 |