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. 2016 May 11;21(5):615. doi: 10.3390/molecules21050615
DDAH Dimethylarginine dimethylamino hydrolase
ADMA Asymmetric dimethylarginine
L-NMMA Monomethyl arginine
NOS Nitric oxide synthase
NO Nitric oxide
SDMA Symmetric dimethylarginine
PRMTs Protein arginine methyl transferases
CAT Cationic amino acid transporter
AGXT2 Alanine-glyoxylate amino transferase 2
PKA Protein kinase A
Akt Protein kinase B
VEGF Vascular endothelial growth factor
iNOS Inducible nitric oxide synthase
TNF-α Tumour necrosis factor α
LDL Low density lipoprotein
IL-1β Interleukin-1β
AT1-R Type 1 angiotensin receptor
DNA Deoxyribonucleic acid
FXR Farnesoid X receptor
HcyNO S-Nitroso-l-homocysteine
NaNO2 Sodium nitrite
NaOH Sodium hydroxide
HCl Hydrochloric acid
Min Minutes
Ki Inhibition constant
µM Micromolar
H2O Water
Cys Cysteine
His Histidine
PaDDAH Pseudomonas aeruginosa dimethylarginine dimethylamino hydrolase
PAD Peptydilarginine deaminase
NaOMe Sodium methoxide
MeOH Methanol
AcOH Acetic acid
NH4Cl Ammonium chloride
PEO Poly(ethylene oxide)
DCM Dichloromethane
TEA Triethylamine
DMAP 4-Dimethylaminopyridine
MsCl Methanesulfonyl chloride
Et2O Diethyl ether
RT Room temperature
NaN3 Sodium azide
DMF N,N-Dimethylformamide
Ph3P Triphenylphosphine
4124W (S)-2-Amino-4-(3-methylguanidino)butanoic acid
Boc tert-Butyloxycarbonyl
M Molar
DEAD Diethyl azodicarboxylate
THF Tetrahydrofuran
DIPEA N,N-Diisopropylethylamine
CH3CN Acetonitrile
SOCl2 Thionyl chloride
SAR Structure activity relationship
IC50 Inhibition constant
L-257 NG-(2-Methoxyethyl)-l-arginine
L-291 NG-(2-Methoxyethyl)-l-arginine methyl ester
Orn Ornithine
Bu Butyl
Z Carboxybenzyl
TFMSA Trifluoromethanesulfonic acid
TFA Trifluoroacetic acid
CDI 1,1′-Carbonyldiimidazole
DBU 1,8-Diazabicyclo[5.4.0]undec-7-ene
h Hours
HATU 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate
mM Millimolar
DMSO Dimethyl sulfoxide
i-BuCOCl Isobutyl chloroformate
NH4OH Ammonium hydroxide
TFAA Trifluoroacetic anhydride
ZnBr2 Zinc bromide
NH2OH.HCl Hydroxylamine hydrochloride
NaHCO3 Sodium bicarbonate
L-VNIO N5-(1-Imino-3-butenyl)-l-ornithine
EtOH Ethanol
EtOAc Ethyl acetate
L-IPO N5-(1-Iminopropyl)-l-ornithine
Cl-NIO N5-(1-Imino-2-chloroethyl)-l-ornithine
PFP Pentafluorophenyl
NaOAc Sodium acetate
ADI Arginine deaminase
HTS High throughput screening
SMTC S-methyl-l-thiocitrulline
ESI-MS Electrospray ionization mass spectrometry
BuLi Butyl lithium
Se Selenium
CuBr2 Copper(II) bromide
NADPH Nicotinamide adenine dinucleotide phosphate
H+/K+ ATPase Proton/potassium ATPase
Ca2+ Calcium 2+ cation
4-HNE 4-Hydroxy-2-nonenal
LOPAC Library of Pharmacologically Active Compounds
NaH Sodium hydride
CS2 Carbon disulfide
BrCN Cyanogen bromide
Å Angstrom
PPIs Proton pump inhibitors
SPR Surface plasmon resonance
CM Carboxymethylated
(Ph3P)2PdCl2 Bis(triphenylphosphine)palladium chloride
CuI Copper(I) iodide
TIPS Triisopropylsilyl
TMS Trimethylsilane
DPPA Diphenylphosphoryl azide