DDAH |
Dimethylarginine dimethylamino hydrolase |
ADMA |
Asymmetric dimethylarginine |
L-NMMA |
Monomethyl arginine |
NOS |
Nitric oxide synthase |
NO |
Nitric oxide |
SDMA |
Symmetric dimethylarginine |
PRMTs |
Protein arginine methyl transferases |
CAT |
Cationic amino acid transporter |
AGXT2 |
Alanine-glyoxylate amino transferase 2 |
PKA |
Protein kinase A |
Akt |
Protein kinase B |
VEGF |
Vascular endothelial growth factor |
iNOS |
Inducible nitric oxide synthase |
TNF-α |
Tumour necrosis factor α |
LDL |
Low density lipoprotein |
IL-1β |
Interleukin-1β |
AT1-R |
Type 1 angiotensin receptor |
DNA |
Deoxyribonucleic acid |
FXR |
Farnesoid X receptor |
HcyNO |
S-Nitroso-l-homocysteine |
NaNO2
|
Sodium nitrite |
NaOH |
Sodium hydroxide |
HCl |
Hydrochloric acid |
Min |
Minutes |
Ki |
Inhibition constant |
µM |
Micromolar |
H2O |
Water |
Cys |
Cysteine |
His |
Histidine |
PaDDAH |
Pseudomonas aeruginosa dimethylarginine dimethylamino hydrolase |
PAD |
Peptydilarginine deaminase |
NaOMe |
Sodium methoxide |
MeOH |
Methanol |
AcOH |
Acetic acid |
NH4Cl |
Ammonium chloride |
PEO |
Poly(ethylene oxide) |
DCM |
Dichloromethane |
TEA |
Triethylamine |
DMAP |
4-Dimethylaminopyridine |
MsCl |
Methanesulfonyl chloride |
Et2O |
Diethyl ether |
RT |
Room temperature |
NaN3
|
Sodium azide |
DMF |
N,N-Dimethylformamide |
Ph3P |
Triphenylphosphine |
4124W |
(S)-2-Amino-4-(3-methylguanidino)butanoic acid |
Boc |
tert-Butyloxycarbonyl |
M |
Molar |
DEAD |
Diethyl azodicarboxylate |
THF |
Tetrahydrofuran |
DIPEA |
N,N-Diisopropylethylamine |
CH3CN |
Acetonitrile |
SOCl2
|
Thionyl chloride |
SAR |
Structure activity relationship |
IC50
|
Inhibition constant |
L-257 |
NG-(2-Methoxyethyl)-l-arginine |
L-291 |
NG-(2-Methoxyethyl)-l-arginine methyl ester |
Orn |
Ornithine |
Bu |
Butyl |
Z |
Carboxybenzyl |
TFMSA |
Trifluoromethanesulfonic acid |
TFA |
Trifluoroacetic acid |
CDI |
1,1′-Carbonyldiimidazole |
DBU |
1,8-Diazabicyclo[5.4.0]undec-7-ene |
h |
Hours |
HATU |
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate |
mM |
Millimolar |
DMSO |
Dimethyl sulfoxide |
i-BuCOCl |
Isobutyl chloroformate |
NH4OH |
Ammonium hydroxide |
TFAA |
Trifluoroacetic anhydride |
ZnBr2
|
Zinc bromide |
NH2OH.HCl |
Hydroxylamine hydrochloride |
NaHCO3
|
Sodium bicarbonate |
L-VNIO |
N5-(1-Imino-3-butenyl)-l-ornithine |
EtOH |
Ethanol |
EtOAc |
Ethyl acetate |
L-IPO |
N5-(1-Iminopropyl)-l-ornithine |
Cl-NIO |
N5-(1-Imino-2-chloroethyl)-l-ornithine |
PFP |
Pentafluorophenyl |
NaOAc |
Sodium acetate |
ADI |
Arginine deaminase |
HTS |
High throughput screening |
SMTC |
S-methyl-l-thiocitrulline |
ESI-MS |
Electrospray ionization mass spectrometry |
BuLi |
Butyl lithium |
Se |
Selenium |
CuBr2
|
Copper(II) bromide |
NADPH |
Nicotinamide adenine dinucleotide phosphate |
H+/K+ ATPase |
Proton/potassium ATPase |
Ca2+
|
Calcium 2+ cation |
4-HNE |
4-Hydroxy-2-nonenal |
LOPAC |
Library of Pharmacologically Active Compounds |
NaH |
Sodium hydride |
CS2
|
Carbon disulfide |
BrCN |
Cyanogen bromide |
Å |
Angstrom |
PPIs |
Proton pump inhibitors |
SPR |
Surface plasmon resonance |
CM |
Carboxymethylated |
(Ph3P)2PdCl2
|
Bis(triphenylphosphine)palladium chloride |
CuI |
Copper(I) iodide |
TIPS |
Triisopropylsilyl |
TMS |
Trimethylsilane |
DPPA |
Diphenylphosphoryl azide |