. 2016 May 11;21(5):615. doi: 10.3390/molecules21050615

Table 2.

Inhibitory parameters for the N-monosubstituted l-arginine analogues with varied N-substituents (R groups) [114,117].

Entry	R–	Inhibition at 1 mM (%)	IC₅₀ (μM)	K_i (μM)
1 ¹	* CH₃OCH₂CH₂–	83	31	13
2 ¹	CH₃NHCH₂CH₂–	29	-	-
3 ¹	(CH₃)₂NHCH₂CH₂–	14	-	-
4 ¹	CH₃SHCH₂CH₂–	80	408	-
5 ¹	FCH₂CH₂–	67	379	-
6 ¹	BnCH₂–	55	866	-
7 ²	CH₃CH₂CH₂–	60	283	90
8 ²	CH₂CHCH₂–	70	207	58
9 ²	CH₂CHCH₂CH₂–	71	189	57
10 ²	CHCCH₂–	83	55	17
11 ²	F₃CCH₂–	41	-	-
12 ²	O₂N–	6	-	-
13 ²	NH₂COCH₂CH₂–	43	-	-

* Denotes L-257 (39) (Scheme 9); ¹ Measured by Ultra Performance Liquid Chromatography-Mass Spectrometry; ² Measured by colorimetric assay.