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Commonly used MRI reporter genes. Ferritin can specifically bind with iron to provide T2 contrast for MRI; The highly expressed TfR in the cells would lead to increased iron uptake to decrease T2 relaxation time; LacZ reporter gene expresses β-galactosidase in cells, which increases MR contrast on T1 weighted images; TYR reporter encodes tyrosinase to synthesize melanin and provide T1 contrast for MRI [21].
