Table 3.
Inhibition of mammalian α-CA with the C-cinnamoyl glycosides 28–35 and phenol 1.
| No. | KI (μM) a | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| hCA I | hCA II | hCA III | hCA IV | hCA VA | hCA VB | hCA VI | hCA VII | hCA IX | hCA XII | hCA XIII | hCA XIV | |
| 28 | 8.5 | 7.0 | >100 | 5.6 | 9.8 | 6.0 | 8.8 | 9.5 | 5.2 | 6.7 | 5.1 | 5.9 |
| 29 | 5.7 | 3.9 | >100 | 4.9 | 8.4 | 4.0 | 6.2 | 6.3 | 5.9 | 6.2 | 4.9 | 5.6 |
| 30 | 5.1 | 7.1 | >100 | 7.8 | 9.5 | 6.9 | 7.7 | 7.1 | 3.3 | 3.9 | 7.2 | 4.6 |
| 31 | 9.3 | 5.5 | >100 | 6.7 | 9.3 | 5.2 | 7.9 | 5.8 | 2.9 | 4.2 | 6.7 | 2.3 |
| 32 | 6.8 | 7.8 | >100 | 8.3 | 7.4 | >100 | >100 | 4.9 | 4.5 | 7.4 | 8.8 | 4.3 |
| 33 | 3.7 | 8.8 | >100 | 7.1 | 4.4 | >100 | >100 | 8.5 | 8.2 | 8.7 | 8.6 | 7.1 |
| 34 | 3.6 | 3.1 | >100 | 9.2 | 3.4 | >100 | 8.1 | 9.0 | 9.2 | 8.4 | 8.6 | >100 |
| 35 | 5.5 | 6.8 | 8.4 | 8.4 | 8.0 | >100 | >100 | 9.3 | 8.2 | 6.8 | >100 | >100 |
| 1 | 10.2 | 5.5 | 2.7 | 9.5 | 218 | 543 | 208 | 710 | 8.8 | 9.2 | 697 | 11.5 |
a From three different assays, errors ± 5%–10% of the reported value, CO2 hydrase, stopped-flow assay.