Table 4.

Structures and hCA inhibition data of dodoneine (36) and its analogues 37–41 by a stopped flow CO₂ hydrase assay [53].

No.	KI (μM) a
	hCA I	hCA II	hCA III	hCA IV	hCA VA	hCA VB	hCA VI	hCA VII	hCA IX	hCA XII	hCA XIII	hCA XIV b
36	5.48	_ c	10.35	9.61	_ c	_ c	_ c	_ c	_ c	_ c	9.27	9.34
37	0.38	_ c	_c	4.12	21.6	13.7	_ c	_ c	32.6	24.5	8.13	7.24
38	0.76	21.8		13.7	8.55	6.32			15.7	10.8	7.89	12.5
39	0.13	36.9		5.36	7.13	1.36	_ c	24.9	3.57	1.48	0.96	2.44
40	_ c	_ c	10.80	_ c	_ c	_ c	_ c	_ c	_ c	_ c	0.91	_ c
41	_ c	_ c	5.13	_ c	_ c	_ c	_ c	_ c	_ c	_ c	0.34	_ c

^a From three different assays, errors ± 5%–10% of the reported value. ^b mCA; ^c Not active > 100.