Table 5.
Inhibition data of human CA isoforms hCA I, II, IV, VII and XII with salvianolic acids 43–45 reported here and the standard sulfonamide inhibitor acetazolamide (AAZ) by a stopped flow CO2 hydrase assay [58].
| No. | KI (nM) a | ||||
|---|---|---|---|---|---|
| hCA I | hCA II | hCA IV | hCA VII | hCA XII | |
| Salvianolic Acid A (43) | >10,000 | 9594.4 | 66.6 | 71.4 | 39.8 |
| Lithospermic Acid (44) | >10,000 | >10,000 | 101.2 | 268.3 | 4.8 |
| Salvianolic Acid B (45) | >10,000 | >10,000 | 65.6 | 35.5 | 453.6 |
| AAZ | 250 | 12 | 74 | 2.5 | 5.7 |
a From three different assays, errors ± 5%–10% of the reported value.