In vivo antitumor activities of LSPS in H22 tumor-bearing mice. Experiment design of H22 mouse hepatocellular carcinoma model (A); Effect of LSPS on tumor weight (B); and average tumor inhibition rate (C); Effect of LSPS on thymus index (D); and spleen index (E). The results are expressed as means ± SD of 10 separate experiments. Compared with negative control (NC), * p < 0.05; ** p < 0.01. CTX, cyclophosphamide (30 mg/kg) treated group; L-LSPS, lotus seed polysaccharide (50 mg/kg) treated group; M-LSPS, lotus seed polysaccharide (100 mg/kg) treated group; H-LSPS, lotus seed polysaccharide (200 mg/kg) treated group.