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The phosphorylation of AKT/PKB (Ser 473) could be inhibited by compound 1, 3a and 3 (A) Representative western blot bands of P-AKT in MDA-MB-231 cells, (B) Representative western blot bands of P-AKT in HGC-27 cells; 1: Control, 2: LY294002 stimulated by 20 µmol/L 20 min before FBS 20 min, 3: FBS incubated at FBS 20 min, 4–6: Compound 3a, 1 and 3 stimulated by 10 µmol/L 2 min before FBS 20 min, respectively).
