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. 2016 Jul 27;21(8):974. doi: 10.3390/molecules21080974

Table 3.

Relative pharmacological potencies of the naturally available methylxanthines ranging from more potent (+++) to less potent (+) (adapted from [24,26,114]).

Systematic Effect Caffeine Theobromine Theophylline
CNS Stimulation +++ + ++
Respiratory Stimulation +++ + ++
Diuresis ++ + +++
Coronary Dilatation + ++ +++
Cardiac Stimulation + ++ +++
Skeletal Muscle Stimulation +++ + ++
Smooth Muscle Relaxation (Bronchodilation) + + +++