Table 2.
Identified biomarkers in ZDF rat urine after treatment with glimepiride, metformin, and their combination compared with the model group.
| Time | Mass | ppm | Formula | Mass Fragments | Structure | Compound |
|---|---|---|---|---|---|---|
| 0.81 | 503.1589 | −4.6 | C18H32O16 | 509 [M − H]−, 383 [M − H − C4H8O4]−, 323 [M − H − C6H12O6]−, 221 [M − H − C10H18O9]−, 110 [M − H − C12H24O14]−, 89 M − H − C15H26O13]− |  |
3-Galactosyl lactose |
| 1.10 | 191.02 | 4.2 | C6H8O7 | 191 [M − H]−, 173 [M − H − OH]−, 129 [M − H − CH2O3]−, 111 [M − H − CH4O4]−, 85 [M − H − CH6O4]−, 67 [M − H − C2H4O6]− |  |
Citric acid |
| 2.75 | 382.0994 | −1.3 | C14H17N5O8 | 382 [M − H]−, 364 [M − H − H2O]−, 302 [M − H − CH4O4]−, 266 [M − H − C4H4O4]−, 206 [M − H − C6H8O6]−, 133 [M − H − C9H7N5O4]− |  |
Succinoadenosine |
| 0.81 | 259.092 | −3.9 | C10H14N2O6 | 259 [M + H]+, 242 [M + H − NH3]+, 215 [M + H − CH2NO]+, 127 [M + H − C5H10NO3]+, 81 [M + H − C5H10N2O5]+ |  |
Ribothymidine |
| 9.05 | 318.3012 | 1.3 | C18H39NO3 | 318 [M + H]+, 300 [M + H − H2O]+, 261 [M + H − C4H9]+, 256 [M + H − C2H8NO]+, 228 [M + H − C5H14O]+, 102 [M + H − C13H30NO]+ |  |
Phytosphingosine |
| 9.27 | 302.3071 | 4.0 | C18H39NO2 | 302 [M + H]+, 284 [M + H − H2O]+, 258 [M + H − C2H4O3]+, 240 [M + H − C2H6O4]+ |  |
Sphinganine |