Table 2.
Antifungal activity of the synthesized thiophene derivatives 5, 7, 8a–b, 9 and 10.
| Compound | Fungal Strains [a] | |||
|---|---|---|---|---|
| Aspergillus fumigates | Syncephalastrum racemosum | Geotricum candidum | Candida albicans | |
| 5 | 13.8 ± 0.42 | 14.1 ± 0.35 | 13.2 ± 0.34 | 10.8 ± 0.22 |
| 7 | 20.6 ± 0.58 | 16.7 ± 0.33 | 22.4 ± 0.36 | 17.6 ± 0.58 |
| 8a | 22.3 ± 0.25 | 16.5 ± 0.25 | 25.8 ± 0.58 | 12.3 ± 0.35 |
| 8b | 20.6 ± 0.35 | 14.8 ± 0.34 | 21.5 ± 0.62 | 10.9 ± 0.18 |
| 9 | 14.8 ± 0.42 | 15.3 ± 0.51 | 14.8 ± 0.46 | 11.9 ± 0.38 |
| 10 | 19.8 ± 0.63 | 16.8 ± 0.46 | 13.9 ± 0.48 | 14.6 ± 0.50 |
| SD [b] | 23.7 ± 0.1 | 19.7 ± 0.2 | 28.7 ± 0.2 | 25.4 ± 0.1 |
[a] Data are expressed as mean ± SD; [b] SD: Standard Drug (amphotericin B).