Table 1.

Equilibrium solubility of megestrol acetate (mg/100 mL) in various pH/surfactant systems where NC—non-centrifuged, C—centrifuged.

Surfactant Concentration	Solubility (mg/100 mL) in Three Different pH
	5.0	7.4	9.0
0.5% Tween 80	6.976 NC	7.873 NC	5.514 NC
	2.406 C	2.146 C	2.280 C
1% Tween 80	12.960 NC	11.359 NC	10.595 NC
	5.580 C	4.754 C	4.279 C
1% Pluronic F68	3.021 NC	2.621 NC	2.322 NC
	0.191 C	0.178 C	0.235 C
2% Pluronic F68	1.631 NC	2.098 NC	1.894 NC
	0.102 C	0.206 C	0.184 C
1% Rofam 70	6.696 NC	5.228 NC	6.233 NC
	2.526 C	2.773 C	2.288 C
2% Rofam 70	10.385 NC	7.541 NC	7.352 NC
	5.187 C	4.906 C	4.749 C