Table 3.

Apparent human AChE inhibition constant (K_i and K_i′) values, equine butyrylcholinesterase (BChE) inhibitory activity and selectivity for AChE for the most active compounds.

Compound	Human AChE		Equine BChE	Selectivity
	Ki /µM	Ki′ /µM	IC50 /µM a	for AchE b
7	40	59	108 ± 18	2.0
10	31	47	59 ± 12	1.4
13	113	165	71 ± 14	0.8
14	56	92	81 ± 18	1.1

^a Values are expressed as mean ± SEM; ^b Selectivity is defined as IC₅₀ (BChE)/IC₅₀ (AChE); values for IC₅₀ (AChE) are shown in Table 2.