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. 2016 May 7;21(5):593. doi: 10.3390/molecules21050593

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Solubilities of nicotinamide (NA) and succinic acid (SA) and the corresponding 2:1 cocrystal (CC) in ethanol (gray solid lines), ethyl acetate (circles, black solid lines), ethanol/ethyl acetate mixtures in (solute-free) solvent mixtures 0.5/0.5 w/w (triangles, black dotted lines) and 0.25/0.75 w/w (diamonds, black dashed lines) at 310.15 K with shortened axes in mole fractions. Lines correspond to the PC-SAFT predictions; symbols refer to the experimental data points of SA (black), the CC (gray) and NA (white).