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. 2016 Aug 4;21(8):1015. doi: 10.3390/molecules21081015

Figure 5.

Figure 5

Inhibitory effects of KIOM-MA128 on the activation of the FcεRI cascade. IgE-sensitized RBL-2H3 cells were treated with KIOM-MA128 for 1 h and then stimulated with DNP-Ag for 10 min. The cells were washed with 1 × DPBS and lysed with cell lysis buffer. The levels of p-SYK, p-LYN, p-FYN, p-ERK, p-p38, p-JNK, p-PLCγ1, p-PKCδ and α-tubulin were determined using the procedure described in the Materials and Methods section. The data represent the mean ± SD values of three independent experiments. (A) p-SYK, p-LYN and p-FYN; (B) p-ERK, p-p38 and p-JNK; (C) p-PLCγ1 and p-PKCδ. # p < 0.05 versus the control group; * p < 0.05 versus the DNP-Ag-treated group.