Figure 12.

Identification of radiometabolites: (a) Aligned radio-HPLC and LC-MS chromatograms (method II). A, radioactivity signal: (+)-[¹⁸F]1 in mouse (plasma, 30 min p.i.); and multi reaction monitoring (MRM) chromatograms (m/z parent/product ion) after incubation of (+)-1 with mouse liver microsomes (MLM) (37 °C, 90 min); B, monohydroxylation (223.1/110.0); C, dihydroxylation (239.1/110.0); D, ketone formation (221.1/110.0); and E, (+)-1 (207.1/110.0). Signal intensities have been adapted; (b) Structures of assigned radiometabolites.