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. 2016 Mar 25;21(4):404. doi: 10.3390/molecules21040404

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of tested A. wilhelmsii extracts and fractions and the reference drug prednisone on LPS‑induced matrix metalloproteinases (MMP) activity. Cells were pre-treated with given extracts (25 μg/mL), prednisone (1 μM; Pred.) or the vehicle (DMSO) only. After 1 h of incubation, the inflammatory response was induced by the addition of LPS (except for the control cells). The activities of MMP-2 (A) and MMP-9 (B) were detected by zymography. The intensity of the digested bands was analyzed by densitometry analysis; (C) The pro-MMP-2/MMP-2 ratio. The results are expressed as means ± SD for three independent experiments. * Significant difference in comparison to vehicle-treated cells (p < 0.05); ** significant difference in comparison to vehicle-treated cells (p < 0.01); *** significant difference in comparison to the vehicle-treated cells (p < 0.001); ^# significant difference in comparison to prednisone-treated cells (p < 0.05); ^### significant difference in comparison to prednisone-treated cells (p < 0.001); (D) The gel representative results of one of the three independent experiments.