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. 2016 Oct 22;21(10):1407. doi: 10.3390/molecules21101407

Table 3.

Structures and activities of indazole derivatives 12a–i.

graphic file with name molecules-21-01407-i003.jpg

Compound No. R Enzyme Inhibition (%) IC50 (nM) a
0.1 μmol/L 0.01 μmol/L
10a H 58.8 27.3 69.1 ± 19.8
12a graphic file with name molecules-21-01407-i011.jpg 35.7 17.1 /
12b graphic file with name molecules-21-01407-i012.jpg 62.3 42.1 38.6 ± 0.2
12c graphic file with name molecules-21-01407-i013.jpg 36.8 9.9 /
12d graphic file with name molecules-21-01407-i014.jpg 31.6 17.4 /
12e graphic file with name molecules-21-01407-i015.jpg 36.7 17.2 /
12f graphic file with name molecules-21-01407-i016.jpg 58.7 28.3 54.0 ± 8.7
12g graphic file with name molecules-21-01407-i017.jpg 60.9 45.1 78.8 ± 14.2
12h graphic file with name molecules-21-01407-i018.jpg 52.7 34.5 102.9 ± 0.6
12i graphic file with name molecules-21-01407-i019.jpg 60.3 35.1 86.2 ± 17.0

a The IC50 or inhibition values shown as the mean ± SD (nM) are calcuated from two separate experiments.