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. 2016 Jul 27;21(8):975. doi: 10.3390/molecules21080975

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of corynoline on the expression of the iNOS, COX-2, HO-1, NQO1 and Nrf2 proteins in LPS-induced RAW264.7 cells. (A) RAW264.7 cells were treated with LPS (150 ng/mL) alone or in combination with corynoline or SFN (each at 1.0 μM). The cells were harvested, and the total protein was extracted at 24 h; the protein levels were measured by Western blotting; (B) Corynoline suppressed the LPS-induced expression of iNOS and COX-2 and increased the LPS-induced expression of HO-1, NQO1 and Nrf2. The bands were densitometrically analyzed using ImageJ software (National Institutes of Health, New York, NY, USA, version 1.50a, http://rsbweb.nih.gov/ij). The relative protein expression levels were calculated and compared with those of the control, which were set to 100%. ** p < 0.05 compared with the vehicle control. * p < 0.05 compared with the LPS-treated group.