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. 2016 Dec 21;21(12):1753. doi: 10.3390/molecules21121753

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Bound sulfur activates the nuclear factor erythroid related factor 2 (Nrf2) system through a structural change of Kelch-like ECH-associated protein 1 (Keap1) and promotion of the AKT/phosphoinositide 3-kinase (PI3K) signaling pathway. ARE: antioxidant response element; GSH: glutathione; HO-1: heme oxygenase 1.