Table 6.
Antitumor activity of triterpene acid extract (TAE) from Ganoderma lingzhi against sarcoma 180 solid tumors in mice and the immune effects of TAE.
| Measurements | Group | ||||
|---|---|---|---|---|---|
| Control | 5-FU | TAE | |||
| Dose (mg/kg days) | - | 25 | 62.5 | 125 | 250 |
| Tumor weight (g) | 1.6 ± 0.7 | 0.7 ± 0.4 ** | 1.2 ± 0.3 * | 1.0 ± 0.2 ** | 0.9 ± 0.2 ** |
| Inhibition ratio (%) | - | 54.0 ± 3.1 | 24.2 ± 2.7 | 37.3 ± 6.2 | 46.6 ± 4.6 |
| Thymus index (mg/g) | 2.5 ± 1.3 | 2.5 ± 0.9 | 2.6 ± 0.4 | 2. 9 ± 0.7 * | 3.1 ± 0.5 * |
| Spleen index (mg/g) | 5. 9 ± 1.2 | 7.9 ± 1.7 * | 6.0 ± 1.4 | 7.0 ± 0.6 * | 7.6 ± 1.3 ** |
The values are the mean ± SD, n = 10; * Significantly different from the control by Duncan test (p < 0.05), ** p < 0.01.