Table 2.
miRNAs associated with epithelial–mesenchymal transition (EMT) and their functions.
| miRNA | Target Gene | Function | Cancer | Ref. |
|---|---|---|---|---|
| miR-200 | ZEB1, ZEB2 | Inhibits EMT and reverses nintedanib resistance | Non-small cell lung cancer | [104] |
| miR-223 | Fbw7 | Induces EMT and confers gemcitabine-resistance | Pancreatic cancer | [105] |
| miR-125b | Sema4C | Inhibits EMT and reverses paclitaxel-resistance | Breast cancer | [106] |
| miR-186 | Twist1 | Inhibits EMT and reverses cisplatin-resistance | Ovarian cancer | [107] |
| miR-15b | PEBP4 | Induces EMT and confers cisplatin resistance | Lung adenocarcinoma | [108] |
| miR-106a | Twist1 | Inhibits EMT and reverses gemcitabine resistance | Hepatocellular carcinoma | [109] |
| miR-203 | Slug | Inhibits EMT and reverses imatinib resistance | Glioblastoma | [110] |
| miR-375 | MTDH | Inhibits EMT and reverses tamoxifen resistance | Breast cancer | [111] |
| miR-27a | RKIP | Induces EMT and confers cisplatin resistance | Lung adenocarcinoma | [112] |
| miR-489 | Smad3 | Inhibits EMT and reverses chemoresistance | Breast cancer | [113] |
| miR-671-5p | FOXM1 | Inhibits EMT and reverses cisplatin resistance | Breast cancer | [114] |