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. 2016 Sep 15;21(9):1236. doi: 10.3390/molecules21091236

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of osimertinib on the accumulation and efflux time-course of [³H]-paclitaxel. (A) The accumulation of [³H]-paclitaxel was measured on parental KB-3-1 and ABCB1 overexpressing KB-C2 drug selected cell line. Columns are the mean of triplicate determinations; error bars represent SD; (B) time courses versus percentage of intracellular [³H]-paclitaxel remaining was plotted to show the effect of osimertinib in the KB-3-1 cell line; and (C) time courses versus percentage of intracellular [³H]-paclitaxel remaining was plotted to show effect of osimertinib in the KB-C2 cell lines. Lines are the mean of triplicate determinations; error bars represent SD. * p < 0.05 versus the control group. Experiments were performed at least three independent times.